• Clinical group: Department of Hematology
  • Chairman: Prof. Shigeru Chiba, MD, PhD
  • Clinical hematology, Hematopoietic stem cell transplantation, Molecular and cellular biology of hematologic malignancies
    E-mail address: schiba-t@md.tsukuba.ac.jp

Other Faculty Members

Associate Professor Yuichi Hasegawa: Hematopoietic stem cell transplantation, Transfusion medicine
Associate Professor Naoshi Obara: Bone marrow failure syndrome, Bone marrow stromal cell regulation
Associate Professor Mamiko Sakata-Yanagimoto: Genetics and molecular mechanisms in malignant lymphoma
Associate Professor Hidekazu Nishikii: Hematopoietic stem cell biology, Bone marrow stromal cell regulation, Megakaryopoiesis
Assistant Professor Yasuhisa Yokoyama: Adult chronic neutropenia, Acute promyelocytic leukemia
Assistant Professor Naoki Kurita: Hematopoietic stem cell transplantation, Clinical studies on HSCT & blood diseases
Assistant Professor Takayasu Kato: Molecular mechanisms of acute myeloid leukemia
Assistant Professor Manabu Kusakabe: Molecular and cellular research in malignant lymphoma

Major Clinical Activities

  1. Diagnosis and Treatment of leukemias, myeloproliferative neoplasms, lymphomas, multiple myelomas, and other hematologic malignancies
  2. Diagnosis and treatment of bone marrow failure syndromes such as aplastic anemia, myelodysplastic syndrome, and related diseases
  3. Allogeneic and autologous hematopoietic stem cell transplantation for patients with above diseases; grafts are bone marrow, mobilized peripheral blood, and cord blood cells
  4. Diagnosis and treatment of hemolytic anemias, immune thrombocytopenic purpura, and other cytopenic diseases
  5. Diagnosis and treatment of coagulopathies

Major Scientific Interests

  1. Molecular mechanisms underlying development of hematologic malignancies, particularly myelodysplastic syndrome and malingant lymphomas (using both patient samples and mouse models)
  2. Stromal cell abnormalities in the bone marrow failure syndromes, including myelosydplastic syndrome (using both patient samples and mouse models)
  3. Mechanisms of hematopoiesis and ex vivo manipulation of hematopoietic stem/progenitor cells (using human cord blood cells and mouse models)
  4. Translational research on hematopoietic cell transplantation

Projects for Regular Students in Doctoral or Master’s Programs

  1. Role of Tet2 in normal hematopoiesis and hematologic malignancies
  2. Identification of stromal cells involved in the bone marrow failure syndromes including myelodyspoastic syndrome
  3. Identification of megakaryocyte (Mgk) progenitors using a new method and application of Mgk progenitors for ex vivo manipulation

Programs for Short Stay Students (one week ~ one trimester)

  1. Learn procedures for sorting progenitor cells from mouse bone marrow and fetal liver using a FACS sorter
  2. Learn blood cell transplantation in mouse model

Message from foreign students in the lab

smileyTanzima Nuhat Sharna, PhD student from Bangladesh
University of Tsukuba, located in southern Ibaraki Prefecture, provides us the opportunity to explore Japanese culture, build our language skill, experience multidisciplinary research environment. Being a part of world-leading innovative university, the department of hematology promotes globalization of researchers by diversified intellectual members. During my work in this laboratory, I came to know about the impressive medical system in Japan. I have received incommensurable support from my supervisor and other lab members to pursue my research. They always encouraged me and motivated to build confidence. Furthermore, I got opportunity to gather high standard theoretical knowledge and practical experience of research in a well-equipped laboratory. We work here with numerous other international students. In addition, we can attend classes and discussions conducted in English which makes an international atmosphere. When I was preparing to apply in the Graduate school of comprehensive human science my supervisor guided me to prepare my applications. Besides, I attended an oral examination for screening process which was conducted in English over the internet. This procedure eliminates my fear of language barrier.  Research in Biomedical science is not very developed in Bangladesh. Therefore, when I shall go back to Bangladesh, I would like to introduce my knowledge from Japan for the betterment of my country.  

smileyCao Sy Luan, PhD student from Vietnam
I am an international student belong the Department of Hematology in University of Tsukuba. First, the reason why I chose this place for studying, because I want to learn about Japanese culture, one of the worthy cultures to learn, study and research about hematological field in professional and modern environment. After more than 3 years studying here, I have been learned a lot of thing, including good characteristics from Japanese, the way of scientific and logical thinking, how to manage experiments and scientific writing skills, the new knowledge not only in hematological but also in clinical, and biomedical filed, and so on. In the Department of Hematology, I have a chance to study and discuss with great and conscientious teachers as well as work together with friendly and kindly lab members. I also got opportunity to attend and represent my study in many conferences in Japan and other countries. I will try to apply as much as possible what I learned from here to contribute to develop my country when I go back. Finally, I greatly appreciate the teaching, helping and encouraging from professor Chiba and all members in the Department of Hematology.

smileyNguyen Thi Minh Yen, PhD student from Vietnam
I feel very proud to be a member of the lab. The friendly environment, the enthusiastic help and the devotion of the teachers made me more motivated to continue my research career. In hematology lab, I have learned a lot of new techniques, new knowledge in biomedical field, pathology, especially the way of thinking scientifically to solve research problems. Along with a great deal of hematological pathology, I believe this is a fascinating field to explore new biological mechanisms and, from that point of view, solves the problem of unique therapeutic drugs for treatment cancer diseases, particularly hematological neoplasm.
Actually, the number of hematologic cancer patients are rising in anxiety in our country. As a student from Vietnam, I think here is a worthy place to contribute and learn to hope that new opportunities for hematologic cancer patients will come true.

smileyRaksha Shrestha, PhD student from Nepal
Enrolling in the Doctoral program in Clinical Hematology at University of Tsukuba was one of the best decisions I have made in my life. Being one of the most highly research-intensive and respected universities in Japan, University of Tsukuba upholds its reputation for excellence with outstanding graduate programs like ours, in the department of hematology. Creative thinking, active discussions and strong mentor-student relationships are some among many positive attributes of the program. I have thoroughly enjoyed learning new techniques in the lab, reading broadly around my areas of interest and hearing about current research from local and visiting academics. A unique blend of interpersonal dynamics, strong work ethic and great camaraderie among the team creates a supportive and an amicable atmosphere in the lab. I believe that the knowledge and experience I acquire here will help me become an independent and competent clinician scientist in future. I feel immensely proud and equally grateful to be a part of this wonderful team at University of Tsukuba. Thank you for making it ‘my home away from home’.

Recent activities

In front of a Soba restaurant (lab members with Prof P. Gaulard.)

Recent Publications

  1. Suehara Y, Sakata-Yanagimoto M, Hattori K, Nanmoku T, Itoh T, Kaji D, Yamamoto G, Abe Y, Narita K, Takeuchi M, Matsue K, Sato T, Noguchi M, Baba N, Sakamoto T, Kusakabe M, Kurita N, Kato T, Yokoyama Y, Nishikii H, Obara N, Hasegawa Y, Chiba S. Liquid biopsy for the identification of intravascular large B-cell lymphoma. Haematologica. (doi: 10.3324/haematol.2017.178830.) [Epub ahead of print]
  2. Fujisawa M, Sakata-Yanagimoto M, Nishizawa S, Komori D, Gershon P, Kiryu M, Tanzima S, Fukumoto K, Enami T, Muratani M, Yoshida K, Ogawa S, Matsue K, Nakamura N, Takeuchi K, Izutsu K, Fujimoto K, Teshima T, Miyoshi H, Gaulard P, Ohshima K, Chiba S. Activation of RHOA-VAV1 signaling in angioimmunoblastic T-cell lymphoma. Leukemia. 2017 (doi: 10.1038/leu.2017.273.) [Epub ahead of print]
  3. Pierini A, Nishikii H, Baker J, Kimura T, Kwon HS, Pan Y, Chen Y, Alvarez M, Strober W, Velardi A, Shizuru JA, Wu JY, Chiba S, Negrin RS. Foxp3+ regulatory T cells maintain the bone marrow microenvironment for B cell lymphopoiesis. Nat Commun. 8:15068, 2017
  4. Nguyen TB, Sakata-Yanagimoto M, Asabe Y,  Matsubara D, Kano J, Yoshida K, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Izutsu K, Nakamura N, Takeuchi K, Miyano H, Ohshima K, Minowa T, Ogawa S, Noguchi M, Chiba S.  Identification of cell-type-specific mutations in nodal T-cell lymphomas. Blood Cancer J. 7:e516, 2017
  5. Makishima H, Yoshizato T, Yoshida K, Sekeres MA, Radivoyevitch T, Suzuki H, Przychodzen B, Nagata Y, Meggendorfer M, Sanada M, Okuno Y, Hirsch C, Kuzmanovic T, Sato Y, Sato-Otsubo A, LaFramboise T, Hosono N, Shiraishi Y, Chiba K, Haferlach C, Kern W, Tanaka H, Shiozawa Y, Gómez-Seguí I, Husseinzadeh HD, Thota S, Guinta KM, Dienes B, Nakamaki T, Miyawaki S, Saunthararajah Y, Chiba S, Miyano S, Shih LY, Haferlach T, Ogawa S, Maciejewski JP. Dynamics of clonal evolution in myelodysplastic syndromes. Nat Genet. 49(2):204-12, 2017
  6. Nishikii H, Kim BS, Yokoyama Y, Chen Y, Baker J, Pierini A, Alvarez M, Mavers M, Maas-Bauer K, Pan Y, Chiba S, Negrin RS. DR3 signaling modulates the function of Foxp3+ regulatory T cells and the severity of acute graft versus host disease. Blood. 128(24):2846-58, 2016
  7. Nagata Y, Kontani K, Enami T, Kataoka K, Ishii R, Totoki Y, Kataoka TR, Hirata M, Aoki K, Nakano K, Kitanaka A, Sakata-Yanagimoto M, Egami S, Shiraishi Y, Chiba K, Tanaka H, Shiozawa Y, Yoshizato T, Suzuki H, Kon A, Yoshida K, Sato Y, Sato-Otsubo A, Sanada M, Munakata W, Nakamura H, Hama N, Miyano S, Nureki O, Shibata T, Haga H, Shimoda K, Katada T, Chiba S, Watanabe T, Ogawa S. Variegated RHOA mutations in adult T-cell leukemia/lymphoma. Blood. 127(5):596-604, 2016
  8. Nishikii H, Kanazawa Y, Umemoto T, Goltsev Y, Matsuzaki Y, Matsushita K, Yamato M, Nolan GP, Negrin R, Chiba S. Unipotent megakaryopoietic pathway bridging hematopoietic stem cells and mature megakaryocytes. Stem Cells. 33(7):2196-207, 2015
  9. Kasenda B, Ferreri AJ, Marturano E, Forst D, Bromberg J, Ghesquieres H, Ferlay C, Blay JY, Hoang-Xuan K, Pulczynski EJ, Fosså A, Okoshi Y, Chiba S, Fritsch K, Omuro A, O'Neill BP, Bairey O, Schandelmaier S, Gloy V, Bhatnagar N, Haug S, Rahner S, Batchelor TT, Illerhaus G, Briel M. First-Line Treatment and Outcome of Elderly Patients with Primary Central Nervous System Lymphoma (PCNSL) - A Systematic Review and Individual Patient Data Meta-Analysis. Ann Oncol. 26(7):1305-13, 2015
  10. Kato T, Sakata-Yanagimoto M, Nishikii H, Miyake Y, Yokayama Y, Asabe Y, Kamada Y, Ueno M, Obara N, Suzukawa K, Hasegawa Y, Kitabayashi I, Uchida K, Hirao A, Yagita H, Kageyama R, Chiba S. Hes1 suppresses acute myeloid leukemia development through FLT3 repression. Leukemia. 29(3):576-85, 2015
  11. Muto H, Sakata-Yanagimoto M, Nagae G, Shiozawa Y, Miyake Y, Yoshida K, Enami T, Kamada Y, Kato T, Uchiba K, Nanmoku T, Obara N, Suzukawa K, Sanada M, Nakamura N, Aburatani H, Ogawa S, Chiba S. Reduced TET2 Function Leads to T-cell Lymphoma with Follicular Helper T cell-like Features in mice. Blood Cancer J. 4:e264, 2014
  12. Sakata-Yanagimoto M, Enami T, Yoshida K, Shiraishi Y, Ishii R, Miyake Y, Muto H, Tsuyama N, Sato-Otsubo A, Okuno Y, Sakata S, Kamada Y, Nakamoto-Matsubara R, Tran NB, Izutsu K, Sato Y, Ohta Y, Furuta J, Shimizu S, Komeno T, Sato Y, Ito T, Noguchi M, Noguchi E, Sanada M, Chiba K, Tanaka H, Suzukawa K, Nanmoku T, Hasegawa Y, Nureki O, Miyano S, Nakamura N, Takeuchi K, Ogawa S, Chiba S. Somatic RHOA mutation in angioimmunoblastic T cell lymphoma. Nat Genet. 46(2):171-5, 2014
  13. Yoshida K, Sanada M, Shiraishi Y, Nowak D, Nagata Y, Yamamoto R, Sato Y, Sato-Otsubo A, Kon A, Nagasaki M, Chalkidis G, Suzuki Y, Shiosaka M, Kawahata R, Yamaguchi T, Otsu M, Obara N, Sakata-Yanagimoto M, Ishiyama K, Mori H, Nolte F, Hofmann WK, Miyawaki S, Sugano S, Haferlach C, Koeffler HP, Shih LY, Haferlach T, Chiba S, Nakauchi H, Miyano S, Ogawa S. Frequent pathway mutations of splicing machinery in myelodysplasia. Nature. 478(7367):64-9, 2011
  14. Sakata-Yanagimoto M, Sakai T, Miyake Y, Saito TI, Maruyama H, Morishita Y, Nakagami-Yamaguchi E, Kumano K, Yagita H, Fukayama M, Ogawa S, Kurokawa M, Yasutomo K, Chiba S. Notch2 signaling is required for proper mast cell distribution and mucosal immunity in the intestine. Blood. 117(1):128-34, 2011