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English
  • Clinical group: Department of Hematology
  • Chairman: Prof. Shigeru Chiba, MD, PhD
  • Clinical hematology, Hematopoietic stem cell transplantation, Molecular and cellular biology of hematologic malignancies
    E-mail address: schiba-t@md.tsukuba.ac.jp

Other Faculty Members

Associate Professor Yuichi Hasegawa: Hematopoietic stem cell transplantation, Transfusion medicine
Associate Professor Naoshi Obara: Bone marrow failure syndrome, Bone marrow stromal cell regulation
Associate Professor Mamiko Sakata-Yanagimoto: Genetics and molecular mechanisms in malignant lymphoma
Associate Professor Hidekazu Nishikii: Hematopoietic stem cell biology, Bone marrow stromal cell regulation, Megakaryopoiesis
Assistant Professor Yasuhisa Yokoyama: Adult chronic neutropenia, Acute promyelocytic leukemia
Assistant Professor Naoki Kurita: Hematopoietic stem cell transplantation, Clinical studies on HSCT & blood diseases
Assistant Professor Takayasu Kato: Molecular mechanisms of acute myeloid leukemia
Assistant Professor Manabu Kusakabe: Molecular and cellular research in malignant lymphoma

Major Clinical Activities

  1. Diagnosis and Treatment of leukemias, myeloproliferative neoplasms, lymphomas, multiple myelomas, and other hematologic malignancies
  2. Diagnosis and treatment of bone marrow failure syndromes such as aplastic anemia, myelodysplastic syndrome, and related diseases
  3. Allogeneic and autologous hematopoietic stem cell transplantation for patients with above diseases; grafts are bone marrow, mobilized peripheral blood, and cord blood cells
  4. Diagnosis and treatment of hemolytic anemias, immune thrombocytopenic purpura, and other cytopenic diseases
  5. Diagnosis and treatment of coagulopathies

Major Scientific Interests

  1. Molecular mechanisms underlying development of hematologic malignancies, particularly myelodysplastic syndrome (using both patient samples and mouse models)
  2. Stromal cell abnormalities in the bone marrow failure syndromes, including myelosydplastic syndrome (using both patient samples and mouse models)
  3. Mechanisms of hematopoiesis and ex vivo manipulation of hematopoietic stem/progenitor cells (using human cord blood cells and mouse models)
  4. Translational research on hematopoietic cell transplantation

Projects for Regular Students in Doctoral or Master’s Programs

  1. Role of Tet2 in normal hematopoiesis and hematologic malignancies
  2. Identification of stromal cells involved in the bone marrow failure syndromes including myelodyspoastic syndrome
  3. Identification of megakaryocyte (Mgk) progenitors using a new method and application of Mgk progenitors for ex vivo manipulation

Programs for Short Stay Students (one week ~ one trimester)

  1. Learn procedures for sorting progenitor cells from mouse bone marrow and fetal liver using a FACS sorter
  2. Learn blood cell transplantation in mouse model

Recent Publications

  1. Suehara Y, Sakata-Yanagimoto M, Hattori K, Nanmoku T, Itoh T, Kaji D, Yamamoto G, Abe Y, Narita K, Takeuchi M, Matsue K, Sato T, Noguchi M, Baba N, Sakamoto T, Kusakabe M, Kurita N, Kato T, Yokoyama Y, Nishikii H, Obara N, Hasegawa Y, Chiba S. Liquid biopsy for the identification of intravascular large B-cell lymphoma. Haematologica. (doi: 10.3324/haematol.2017.178830.) [Epub ahead of print]
  2. Fujisawa M, Sakata-Yanagimoto M, Nishizawa S, Komori D, Gershon P, Kiryu M, Tanzima S, Fukumoto K, Enami T, Muratani M, Yoshida K, Ogawa S, Matsue K, Nakamura N, Takeuchi K, Izutsu K, Fujimoto K, Teshima T, Miyoshi H, Gaulard P, Ohshima K, Chiba S. Activation of RHOA-VAV1 signaling in angioimmunoblastic T-cell lymphoma. Leukemia. 2017 (doi: 10.1038/leu.2017.273.) [Epub ahead of print]
  3. Pierini A, Nishikii H, Baker J, Kimura T, Kwon HS, Pan Y, Chen Y, Alvarez M, Strober W, Velardi A, Shizuru JA, Wu JY, Chiba S, Negrin RS. Foxp3+ regulatory T cells maintain the bone marrow microenvironment for B cell lymphopoiesis. Nat Commun. 8:15068, 2017
  4. Nguyen TB, Sakata-Yanagimoto M, Asabe Y,  Matsubara D, Kano J, Yoshida K, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Izutsu K, Nakamura N, Takeuchi K, Miyano H, Ohshima K, Minowa T, Ogawa S, Noguchi M, Chiba S.  Identification of cell-type-specific mutations in nodal T-cell lymphomas. Blood Cancer J. 7:e516, 2017
  5. Makishima H, Yoshizato T, Yoshida K, Sekeres MA, Radivoyevitch T, Suzuki H, Przychodzen B, Nagata Y, Meggendorfer M, Sanada M, Okuno Y, Hirsch C, Kuzmanovic T, Sato Y, Sato-Otsubo A, LaFramboise T, Hosono N, Shiraishi Y, Chiba K, Haferlach C, Kern W, Tanaka H, Shiozawa Y, Gómez-Seguí I, Husseinzadeh HD, Thota S, Guinta KM, Dienes B, Nakamaki T, Miyawaki S, Saunthararajah Y, Chiba S, Miyano S, Shih LY, Haferlach T, Ogawa S, Maciejewski JP. Dynamics of clonal evolution in myelodysplastic syndromes. Nat Genet. 49(2):204-12, 2017
  6. Nishikii H, Kim BS, Yokoyama Y, Chen Y, Baker J, Pierini A, Alvarez M, Mavers M, Maas-Bauer K, Pan Y, Chiba S, Negrin RS. DR3 signaling modulates the function of Foxp3+ regulatory T cells and the severity of acute graft versus host disease. Blood. 128(24):2846-58, 2016
  7. Nagata Y, Kontani K, Enami T, Kataoka K, Ishii R, Totoki Y, Kataoka TR, Hirata M, Aoki K, Nakano K, Kitanaka A, Sakata-Yanagimoto M, Egami S, Shiraishi Y, Chiba K, Tanaka H, Shiozawa Y, Yoshizato T, Suzuki H, Kon A, Yoshida K, Sato Y, Sato-Otsubo A, Sanada M, Munakata W, Nakamura H, Hama N, Miyano S, Nureki O, Shibata T, Haga H, Shimoda K, Katada T, Chiba S, Watanabe T, Ogawa S. Variegated RHOA mutations in adult T-cell leukemia/lymphoma. Blood. 127(5):596-604, 2016
  8. Nishikii H, Kanazawa Y, Umemoto T, Goltsev Y, Matsuzaki Y, Matsushita K, Yamato M, Nolan GP, Negrin R, Chiba S. Unipotent megakaryopoietic pathway bridging hematopoietic stem cells and mature megakaryocytes. Stem Cells. 33(7):2196-207, 2015
  9. Kasenda B, Ferreri AJ, Marturano E, Forst D, Bromberg J, Ghesquieres H, Ferlay C, Blay JY, Hoang-Xuan K, Pulczynski EJ, Fosså A, Okoshi Y, Chiba S, Fritsch K, Omuro A, O'Neill BP, Bairey O, Schandelmaier S, Gloy V, Bhatnagar N, Haug S, Rahner S, Batchelor TT, Illerhaus G, Briel M. First-Line Treatment and Outcome of Elderly Patients with Primary Central Nervous System Lymphoma (PCNSL) - A Systematic Review and Individual Patient Data Meta-Analysis. Ann Oncol. 26(7):1305-13, 2015
  10. Kato T, Sakata-Yanagimoto M, Nishikii H, Miyake Y, Yokayama Y, Asabe Y, Kamada Y, Ueno M, Obara N, Suzukawa K, Hasegawa Y, Kitabayashi I, Uchida K, Hirao A, Yagita H, Kageyama R, Chiba S. Hes1 suppresses acute myeloid leukemia development through FLT3 repression. Leukemia. 29(3):576-85, 2015
  11. Muto H, Sakata-Yanagimoto M, Nagae G, Shiozawa Y, Miyake Y, Yoshida K, Enami T, Kamada Y, Kato T, Uchiba K, Nanmoku T, Obara N, Suzukawa K, Sanada M, Nakamura N, Aburatani H, Ogawa S, Chiba S. Reduced TET2 Function Leads to T-cell Lymphoma with Follicular Helper T cell-like Features in mice. Blood Cancer J. 4:e264, 2014
  12. Sakata-Yanagimoto M, Enami T, Yoshida K, Shiraishi Y, Ishii R, Miyake Y, Muto H, Tsuyama N, Sato-Otsubo A, Okuno Y, Sakata S, Kamada Y, Nakamoto-Matsubara R, Tran NB, Izutsu K, Sato Y, Ohta Y, Furuta J, Shimizu S, Komeno T, Sato Y, Ito T, Noguchi M, Noguchi E, Sanada M, Chiba K, Tanaka H, Suzukawa K, Nanmoku T, Hasegawa Y, Nureki O, Miyano S, Nakamura N, Takeuchi K, Ogawa S, Chiba S. Somatic RHOA mutation in angioimmunoblastic T cell lymphoma. Nat Genet. 46(2):171-5, 2014
  13. Yoshida K, Sanada M, Shiraishi Y, Nowak D, Nagata Y, Yamamoto R, Sato Y, Sato-Otsubo A, Kon A, Nagasaki M, Chalkidis G, Suzuki Y, Shiosaka M, Kawahata R, Yamaguchi T, Otsu M, Obara N, Sakata-Yanagimoto M, Ishiyama K, Mori H, Nolte F, Hofmann WK, Miyawaki S, Sugano S, Haferlach C, Koeffler HP, Shih LY, Haferlach T, Chiba S, Nakauchi H, Miyano S, Ogawa S. Frequent pathway mutations of splicing machinery in myelodysplasia. Nature. 478(7367):64-9, 2011
  14. Sakata-Yanagimoto M, Sakai T, Miyake Y, Saito TI, Maruyama H, Morishita Y, Nakagami-Yamaguchi E, Kumano K, Yagita H, Fukayama M, Ogawa S, Kurokawa M, Yasutomo K, Chiba S. Notch2 signaling is required for proper mast cell distribution and mucosal immunity in the intestine. Blood. 117(1):128-34, 2011